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Structure-guided optimisation of NMR screen hit The successful soaking of NMR hit analogues 3032 into TRF1 TRFH crystals validated their site-specific binding and opened up an opportunity to design more analogues in silico

coli , leads to a shift in microbial composition that disrupts normal metabolic processes [82, 83]

Standard insulin syringes (100-unit / 1mL) are commonly used for drawing bacteriostatic water during peptide reconstitution

No claims are made regarding biological outcomes, clinical relevance, or applicability outside of investigational research settings

doi: 10.1016/j.xphs.2024.03.001 23 JangB

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